First-in-Human Studies of [ 18 F] Fluorohydroxyphenethylguanidines

First-in-Human Studies of Brain PDE2A

Authors:Mika Naganawa1*, Rikki N Waterhouse2*, Nabeel Nabulsi, Shu-Fei Lin1, David Labaree1, Jim Ropchan1, Sanela Tarabar2, Nicholas DeMartinis2, Adam Ogden, Anindita Banerjee2, Yiyun Huang1, Richard E. Carson1 1PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 2Pfizer Worldwide Research and Development, Cambridge, MA *Co-first authors Correspond...

[ 18 F ] Fdg - Pet

Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.

This report is concerned with an efficient, Cu(I)-mediated method for the radiosynthesis of [(18)F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Three (18)F-labelled radiotracer candidates were synthesised from [(18)F]fluoride ions as proof of principle. The new protocol is widely applicable for the synthes...

[Interpretation of thyroid incidentalomas in (18)F-FDG PET/CT studies].

OBJECTIVE Thyroid findings or incidentalomas in (18)F-FDG PET/CT studies are relatively frequent, being its clinical significance subject of controversy. The aim of this study was to show our experience in the detection of thyroid incidentalomas by PET/CT studies as well as its follow up. MATERIAL AND METHODS A retrospective and descriptive review was conducted on patients who had thyroid inc...

18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging

BACKGROUND The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging have been developed. To some extent, they all lack the optimal balance between efficient radiochemistry and favorable in vivo characteristics. METHODS A new clickable olate p...